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Clarke\u4e3a\u8fd9\u5bb6\u65b0\u516c\u53f8\u63d0\u4f9b\u4e86250\u4e07\u7f8e\u5143\u7684A\u8f6e\u878d\u8d44\u3002Christoph\u5bf9\u8fd9\u9879\u5de5\u4f5c\u5145\u6ee1\u4e86\u6fc0\u60c5\uff0c\u800cJohn\u5219\u63d0\u4f9b\u4e86\u521d\u521b\u516c\u53f8\u9700\u8981\u7684\u8d44\u5386\u3002\u65af\u514b\u91cc\u666e\u65af\u7814\u7a76\u6240\u7684\u79d1\u5b66\u5bb6\u548c\u751f\u7269\u4f01\u4e1a\u5bb6Paul Schimmel\u52a0\u5165\u56e2\u961f\uff0c\u4e0ePhil\u548c\u4ed6\u7684\u56db\u4f4d\u5408\u4f5c\u8005\u4e00\u8d77\u7ec4\u5efa\u4e86\u516c\u53f8\u7684\u521b\u59cb\u56e2\u961f\u3002\u5e94Phil\u7684\u8981\u6c42\uff0cPaul\u5728\u90a3\u91cc\u5e2e\u52a9\u8fd0\u8425\u8fd9\u5bb6\u521d\u521b\u516c\u53f8\uff0c\u4ed6\u7684\u9ad8\u660e\u4e4b\u5904\u5728\u4e8e\u5c06\u516c\u53f8\u6700\u521d\u7684\u201cPrecision Therapeutics\u201d\u6539\u540d\u4e3a\u201cAlnylam Pharmaceutics\u201d\u3002Paul\u6700\u559c\u6b22\u7684\u963f\u59e8\u662f\u4e00\u4f4d\u963f\u62c9\u4f2f\u5b66\u8005\uff0c\u6307\u51fa\u201cal 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Nelson\uff0c\u6210\u4e3a\u4e86B\u8f6e\u6295\u8d44\u8005\uff0c\u5706\u6ee1\u5b8c\u6210Alnylam\u7684\u8fd9\u4e00\u8f6e\u878d\u8d44\u3002\u4ed6\u4eec\u60f3\u77e5\u9053\u6211\u662f\u5426\u6709\u5174\u8da3\u52a0\u5165Alnylam\uff0c\u62c5\u4efb\u9996\u5e2d\u6267\u884c\u5b98\uff08CEO\uff09\uff0c\u5e76\u5efa\u8bae\u6211\u4e0ePhil\u540e\u7eed\u4f1a\u9762\uff0c\u542c\u542c\u4ed6\u4ece\u79d1\u5b66\u7684\u89d2\u5ea6\u5bf9\u65b0\u516c\u53f8\u7684\u770b\u6cd5\u3002\u8981\u62d2\u7edd\u4e0ePhil\u7684\u4f1a\u9762\u662f\u4e00\u4ef6\u5f88\u56f0\u96be\u7684\u4e8b\u60c5\uff0c\u90a3\u5e74\u590f\u5929\u665a\u4e9b\u65f6\u5019\u6211\u548cPhil\u8fdb\u884c\u4e86\u4ea4\u8c08\u3002\u867d\u7136\u6211\u5f88\u6ee1\u610f\u81ea\u5df1\u5728\u5343\u79a7\u5236\u836f\u7684\u5de5\u4f5c\uff0c\u4f46\u6211\u5f00\u59cb\u8fdb\u4e00\u6b65\u6df1\u5165\u7814\u7a76RNAi\uff0c\u6e05\u695a\u5730\u8ba4\u8bc6\u5230\u8be5\u6280\u672f\u6709\u6f5c\u529b\u521b\u9020\u4e00\u7c7b\u4ece\u672a\u6709\u8fc7\u7684\u521b\u65b0\u836f\u7269\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u5f88\u660e\u663e\uff0c\u5b9e\u73b0siRNA\u7684\u9012\u9001\u5c06\u662f\u8fd9\u9879\u6280\u672f\u7684\u4e00\u4e2a\u5173\u952e\u969c\u788d\u3002<\/p>\n\n\n\n<p>\u90a3\u4e00\u6bb5\u65f6\u95f4\uff0c\u6ee1\u8111\u5b50\u90fd\u662fRNAi\u3002\u6bcf\u5929\u65e9\u4e0a\u5f00\u8f66\u53bb\u4e0a\u73ed\u7684\u8def\u4e0a\uff0c\u6211\u90fd\u65e0\u6cd5\u505c\u6b62\u601d\u8003RNAi\u4f5c\u4e3a\u4e00\u79cd\u65b0\u7597\u6cd5\u7684\u6f5c\u529b\u3002\u8fd9\u5c31\u50cf\u572870\u5e74\u4ee3\u672b\u621680\u5e74\u4ee3\u521d\u88ab\u9080\u8bf7\u4f7f\u7528Georges Kohler\u548cC\u00e9sar Milstein\u7684\u6280\u672f\u548c\u77e5\u8bc6\u4ea7\u6743\u521b\u529e\u4e00\u5bb6\u5355\u514b\u9686\u6297\u4f53\u65b0\u836f\u516c\u53f8\u4e00\u6837\u3002\u7136\u800c\uff0c\u8bb8\u591a\u670b\u53cb\u548c\u540c\u4e8b\uff0c\u5305\u62ec\u6211\u7684\u4e24\u4e2a\u5e74\u7eaa\u5927\u7684\u5b69\u5b50\uff0c\u90fd\u8ba4\u4e3a\u6211\u72af\u4e86\u4e00\u4e2a\u9519\u8bef\uff0c\u5e76\u544a\u8beb\u6211\u4e0d\u8981\u8f7b\u4e3e\u5984\u52a8\u3002\u5f7c\u65f6\uff0c\u5728\u201c\u57fa\u56e0\u7ec4\u5b66\u6ce1\u6cab\u201d\u7834\u706d\u540e\uff0c\u751f\u7269\u6280\u672f\u884c\u4e1a\u8fdb\u5165\u4e86\u4e00\u4e2a\u9ed1\u6697\u7684\u5bd2\u51ac\uff0c\u5bf9\u65b0\u79d1\u5b66\u7684\u6295\u8d44\u6781\u4e0d\u53d7\u6b22\u8fce\u3002\u5b9e\u73b0siRNA\u9012\u9001\u7684\u6311\u6218\u80fd\u5426\u88ab\u514b\u670d\u5e76\u5728\u5408\u7406\u7684\u65f6\u95f4\u5185\u5b8c\u6210\uff1f\u8fd9\u5bb6\u65b0\u516c\u53f8\u80fd\u5426\u6210\u529f\u7b79\u96c6\u5230\u521b\u9020\u4e00\u9879\u6210\u529f\u7684\u751f\u7269\u6280\u672f\u6240\u9700\u7684\u6570\u5341\u4ebf\u7f8e\u5143\uff1f\u662f\u5426\u6709\u53ef\u80fd\u6446\u8131\u4f20\u7edf\u836f\u7269\u53d1\u73b0\u7684\u6251\u6714\u8ff7\u79bb\u800c\u5efa\u7acb\u4e00\u4e2a\u53ef\u9760\u7684\u3001\u53ef\u590d\u5236\u7684\u3001\u6a21\u5757\u5316\u7684\u7814\u53d1\u5e73\u53f0\uff0c\u4ece\u800c\u5b9e\u73b0\u53ef\u6301\u7eed\u7684\u521b\u65b0\uff1f\u8fd9\u4e00\u4e2a\u4e2a\u95ee\u9898\u4e00\u76f4\u5728\u6211\u7684\u773c\u524d\u3001\u8111\u6d77\u91cc\u76d8\u65cb\uff0c\u4e00\u65f6\u95f4\u6211\u6b32\u7f62\u4e0d\u80fd\u3002<\/p>\n\n\n\n<p>\u6211\u7684\u51b3\u5b9a\u4e5f\u56e0\u4e3a\u5343\u79a7\u5236\u836f\u6b63\u6240\u5904\u7684\u6fc0\u52a8\u4eba\u5fc3\u7684\u65f6\u671f\u800c\u53d8\u5f97\u590d\u6742\u3002\u4f5c\u4e3a\u4e00\u6b3e\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u5728\u7814\u836f\u7269\uff0c\u540c\u7c7b\u9996\u521b\u7684\u86cb\u767d\u9176\u4f53\u6291\u5236\u5242Velcade\uff08\u787c\u66ff\u4f50\u7c73\uff09\u6b63\u5904\u4e8e\u52a0\u901f\u5ba1\u6279\u9636\u6bb5\uff0c\u516c\u53f8\u9996\u5e2d\u6267\u884c\u5b98Mark Levin\u5e0c\u671b\u6211\u7559\u4e0b\u6765\u5e2e\u52a9\u516c\u53f8\u8fdb\u5165\u65b0\u7684\u5546\u4e1a\u5316\u9636\u6bb5\u3002\u4e0e\u6b64\u540c\u65f6\uff0cMark\u4e5f\u662f\u6211\u7684\u670b\u53cb\u548c\u5bfc\u5e08\uff0c\u4ed6\u9f13\u52b1\u6211\u53bb\u8ffd\u6c42\u6700\u8ba9\u6211\u5174\u594b\u4e0d\u5df2\u7684\u4e1c\u897f\u3002\u90a3\u65f6\u7684\u6211\u4e0d\u65ad\u60f3\u5230\u7684\u5c31\u662f\uff0c\u5982\u679c\u6280\u672f\u969c\u788d\u80fd\u591f\u88ab\u514b\u670d\uff0cRNAi\u7597\u6cd5\u5c06\u662f\u4e00\u4e2a\u4e0d\u5bb9\u653e\u5f03\u7684\u5343\u8f7d\u96be\u9022\u7684\u5927\u597d\u673a\u4f1a\u3002<\/p>\n\n\n\n<p>\u5c31\u4e2a\u4eba\u800c\u8a00\uff0c\u90a3\u65f6\u6211\u521a\u521a\u518d\u5a5a\uff0c\u5728\u6bdb\u91cc\u6c42\u65af\u5ea6\u871c\u6708\u3002Alnylam\u8bf7\u6211\u51fa\u4efb\u516c\u53f8CEO\u7684\u8058\u4e66\u5bc4\u5230\u4e86\u871c\u6708\u5957\u623f\u3002\u673a\u7f18\u5de7\u5408\uff0c\u6536\u5230\u8058\u4e66\u7684\u90a3\u4e00\u523b\uff0c\u6211\u89c9\u5f97\u4e00\u6761\u5168\u65b0\u7684\u5927\u9053\u5728\u6211\u7684\u9762\u524d\u548c\u811a\u4e0b\u3002\u6211\u4e0d\u518d\u72b9\u8c6b\uff0c\u51b3\u5b9a\u5192\u9669\u4e00\u8bd5\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u4e8c\u3001\u7a7f\u8d8a\u77e5\u8bc6\u4ea7\u6743\u7684\u4e1b\u6797<\/h2>\n\n\n\n<p>2002\u5e7412\u6708\uff0c\u6211\u4f5c\u4e3aAlnylam\u7684\u65b0\u4efb\u9996\u5e2d\u6267\u884c\u5b98\uff0c\u53c2\u52a0\u4e86\u9996\u6b21\u8463\u4e8b\u4f1a\u4f1a\u8bae\u3002\u6211\u5411\u8463\u4e8b\u4eec\u9610\u8ff0\u4e86\u6211\u7684\u613f\u666f\u548c\u4f7f\u547d\uff0c\u4e3a\u516c\u53f8\u6307\u660e\u4e86\u524d\u8fdb\u7684\u65b9\u5411\u3002\u8fd9\u662f\u6211\u5728Millennium\u65f6\u4eceLevin\u90a3\u91cc\u5b66\u5230\u7684\u4e00\u62db\u3002\u6211\u4eec\u7684\u613f\u666f\u662f\uff1a\u4ee5\u751f\u7269\u5b66\u9769\u547d\u4e3a\u52a8\u529b\uff0c\u4fc3\u8fdb\u4eba\u7c7b\u5065\u5eb7\u3002\u6211\u4eec\u7684\u4f7f\u547d\u662f\uff1a\u6253\u9020\u4e00\u4e2a\u72ec\u7acb\u7684\u3001\u9876\u7ea7\u7684\u3001\u57fa\u4e8eRNAi\u7684\u751f\u7269\u5236\u836f\u516c\u53f8\u3002\u5982\u4eca\u8fd9\u4e2a\u613f\u666f\u4e0e\u4f7f\u547d\u4e5f\u4f34\u968f\u7740Alnylam\u7684\u53d1\u5c55\u4fdd\u7559\u4e86\u4e0b\u6765\uff0c\u6cbf\u7528\u81f3\u4eca\uff0c\u4ece\u672a\u6539\u53d8\u3002<\/p>\n\n\n\n<p>\u4e3a\u4e86\u8fbe\u6210\u8fd9\u4e00\u4f7f\u547d\uff0cAlnylam\u9700\u8981\u66f4\u591a\u7684\u65f6\u95f4\u4e0e\u91d1\u94b1\u3002\u6211\u4eec\u8ba1\u5212\u9700\u898110\u4ebf-20\u4ebf\u7f8e\u5143\u7684\u8d44\u91d1\uff0c\u752810\u5e74-20\u5e74\u7684\u65f6\u95f4\u6765\u5b8c\u6210\u8fd9\u4e2a\u76ee\u6807\u3002\u540c\u65f6\u6211\u4e5f\u660e\u767d\uff0cRNAi\u6280\u672f\u521a\u521a\u5174\u8d77\uff0c\u62a2\u5360\u5f3a\u5927\u7684\u77e5\u8bc6\u4ea7\u6743\u5730\u4f4d\u81f3\u5173\u91cd\u8981\u3002<\/p>\n\n\n\n<p>\u56e0\u6b64\uff0c\u5728\u6211\u521a\u4e0a\u4efb\u7684\u7b2c\u4e00\u5929\u5c31\u98de\u5230\u4e86\u6155\u5c3c\u9ed1\uff0c\u4e0e\u9a6c\u666e\u6280\u672f\u8bb8\u53ef\u529e\u516c\u5ba4\uff08\u5f53\u65f6\u53eb\u505aGarching Innovation\uff09\u8fdb\u884c\u4e86\u4f1a\u8c08\uff0c\u4e3a\u7684\u5c31\u662f\u7b7e\u8ba2Tuschl I\u548cTusch&nbsp;II\u4e13\u5229\u5bb6\u65cf\u7684\u8bb8\u53ef\u534f\u8bae\u3002\u9a6c\u666e\u4ee3\u8868\u4e86\u56db\u5bb6\u5b66\u672f\u673a\u6784\uff08\u5176\u4ed6\u4e09\u5bb6\u5206\u522b\u9ebb\u7701\u7406\u5de5\u5b66\u9662\u3001\u6000\u7279\u6d77\u5fb7\u7814\u7a76\u6240\u548c\u9a6c\u8428\u8bf8\u585e\u5927\u5b66\uff09\u4e0e\u6211\u4eec\u8c08\u5224\u3002\u503c\u5f97\u4e00\u63d0\u5230\u662f\uff0c\u6d3e\u9a6c\u666e\u4f5c\u4e3a\u8c08\u5224\u4ee3\u8868\uff0c\u662f\u56e0\u4e3aTuschl II\u4e13\u5229\u5bb6\u65cf\u662f\u5b83\u7684\u4e13\u5c5e\u53d1\u660e\uff0c\u800cTuschl 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