{"id":40654,"date":"2026-03-11T17:21:05","date_gmt":"2026-03-11T09:21:05","guid":{"rendered":"http:\/\/cxounion.cn\/?p=40654"},"modified":"2026-03-11T17:21:10","modified_gmt":"2026-03-11T09:21:10","slug":"%e5%8a%a0%e7%a7%91%e6%80%9d%e8%8d%af%e4%b8%9a%e5%85%ac%e5%b8%832025%e5%b9%b4%e5%ba%a6%e4%b8%9a%e7%bb%a9","status":"publish","type":"post","link":"http:\/\/cxounion.cn\/index.php\/2026\/03\/11\/%e5%8a%a0%e7%a7%91%e6%80%9d%e8%8d%af%e4%b8%9a%e5%85%ac%e5%b8%832025%e5%b9%b4%e5%ba%a6%e4%b8%9a%e7%bb%a9\/","title":{"rendered":"\u52a0\u79d1\u601d\u836f\u4e1a\u516c\u5e032025\u5e74\u5ea6\u4e1a\u7ee9"},"content":{"rendered":"\n

\u9996\u4e2a\u5546\u4e1a\u5316\u4ea7\u54c1\u6208\u6765\u96f7\u585e\u7247\u5728\u4e2d\u56fd\u83b7\u6279\u5e76\u7eb3\u5165\u533b\u4fdd<\/p>\n\n\n\n

pan-KRAS\u53ca\u521b\u65b0ADC\u7ba1\u7ebf\u6301\u7eed\u63a8\u8fdb<\/p>\n\n\n\n

\u5317\u4eac\u3001\u4e0a\u6d77\u548c\u6ce2\u58eb\u987f2026\u5e743\u670810\u65e5 \/\u7f8e\u901a\u793e\/ — \u52a0\u79d1\u601d\u836f\u4e1a\u96c6\u56e2\u6709\u9650\u516c\u53f8\uff08HKEX\uff1a1167\uff0c”\u52a0\u79d1\u601d”\u6216”\u516c\u53f8”\uff09\u4eca\u65e5\u516c\u5e03\u622a\u81f32025\u5e7412\u670831\u65e5\u6b62\u5e74\u5ea6\u4e1a\u7ee9\uff0c\u5e76\u66f4\u65b0\u516c\u53f8\u6838\u5fc3\u7814\u53d1\u7ba1\u7ebf\u8fdb\u5c55\u3002<\/p>\n\n\n\n

2025\u5e74\uff0c\u516c\u53f8\u5728KRAS\u9776\u5411\u6cbb\u7597\u53ca\u521b\u65b0ADC\u5e73\u53f0\u65b9\u9762\u53d6\u5f97\u591a\u9879\u5173\u952e\u8fdb\u5c55\uff0c\u5176\u4e2d\u5305\u62ecKRAS G12C\u6291\u5236\u5242\u6208\u6765\u96f7\u585e\uff08glecirasib\uff09\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\u5e76\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\uff0cpan-KRAS\u6291\u5236\u5242JAB-23E73\u4e0e\u963f\u65af\u5229\u5eb7\u8fbe\u6210\u603b\u91d1\u989d20.15\u4ebf\u7f8e\u5143\uff08\u542b\u9996\u4ed8\u6b3e1\u4ebf\u7f8e\u5143\uff09\u7684\u5408\u4f5c\u534f\u8bae\uff0c\u4ee5\u53caEGFR-KRAS G12Di tADC\u548cHER2-STINGa iADC\u8fdb\u5165IND\u51c6\u5907\u9636\u6bb5\u3002<\/p>\n\n\n\n

\u52a0\u79d1\u601d\u8463\u4e8b\u957f\u517c\u8054\u5e2d\u9996\u5e2d\u6267\u884c\u5b98\u738b\u5370\u7965\u535a\u58eb\u8868\u793a\uff1a”2025\u5e74\u662f\u52a0\u79d1\u601d\u6210\u7acb\u7684\u7b2c\u5341\u5e74\uff0c\u4e5f\u662f\u516c\u53f8\u8fce\u6765\u9996\u4e2a\u6536\u83b7\u671f\u7684\u4e00\u5e74\u3002\u6208\u6765\u96f7\u585e\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\u5e76\u8fdb\u5165\u533b\u4fdd\uff0c\u6807\u5fd7\u7740\u516c\u53f8\u521b\u65b0\u7814\u53d1\u80fd\u529b\u8fc8\u5165\u5546\u4e1a\u5316\u9636\u6bb5\u3002\u540c\u65f6\uff0cJAB-23E73\u5728\u8fc7\u53bb\u4e00\u5e74\u53d6\u5f97\u91cd\u8981\u8fdb\u5c55\uff0c\u4e0d\u4ec5\u5728\u4e2d\u56fd\u5b8c\u6210\u4e00\u671f\u5242\u91cf\u722c\u5761\u8bd5\u9a8c\uff0c\u53d6\u5f97\u4e86\u79ef\u6781\u7684\u4e34\u5e8a\u6570\u636e\uff0c\u5e76\u63a8\u52a8\u5176\u4e00\u7ebf\u80f0\u817a\u764c\u8054\u5408\u6cbb\u7597\u8bd5\u9a8c\u83b7\u5f97\u6279\u51c6\u3002\u672a\u6765\uff0c\u6211\u4eec\u5c06\u7ee7\u7eed\u805a\u7126KRAS\u9776\u5411\u6cbb\u7597\u548c\u521b\u65b0\u529f\u80fd\u6027\u8f7d\u8377ADC\u5e73\u53f0\uff0c\u5305\u62ectADC\u5e73\u53f0\u548ciADC\u5e73\u53f0\uff0c\u63a8\u52a8\u66f4\u591a\u521b\u65b0\u7597\u6cd5\u8fdb\u5165\u4e34\u5e8a\u548c\u5e02\u573a\uff0c\u4e3a\u5168\u7403\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002”<\/p>\n\n\n\n

\u6838\u5fc3\u7ba1\u7ebf\u8fdb\u5c55<\/strong><\/p>\n\n\n\n

\u6208\u6765\u96f7\u585e\uff08<\/strong>glecirasib<\/strong>\uff0c<\/strong>KRAS G12C<\/strong>\u6291\u5236\u5242\uff09<\/strong><\/p>\n\n\n\n

2025\u5e74\uff0c\u6208\u6765\u96f7\u585e\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff0c\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u7ebf\u7cfb\u7edf\u6cbb\u7597\u7684KRAS G12C\u7a81\u53d8\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\uff0c\u5e76\u4e8e\u540c\u5e74\u7eb3\u5165\u56fd\u5bb6\u533b\u4fdd\u76ee\u5f55\u3002\u8be5\u4ea7\u54c1\u7531\u5408\u4f5c\u4f19\u4f34\u827e\u529b\u65af\u8d1f\u8d23\u5728\u4e2d\u56fd\u7684\u5546\u4e1a\u5316\u63a8\u5e7f\u3002\u81ea2025\u5e746\u6708\u81f312\u6708\uff0c\u52a0\u79d1\u601d\u786e\u8ba4\u6536\u5165855\u4e07\u5143\u3002<\/p>\n\n\n\n

\u6b64\u5916\uff0c\u6208\u6765\u96f7\u585e\u4e0eSHP2\u6291\u5236\u5242sitneprotafib\uff08JAB-3312\uff09\u8054\u5408\u7528\u4e8e\u4e00\u7ebf\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6cbb\u7597\u7684III\u671f\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u4e2d\u56fd\u5f00\u5c55\u3002\u8be5\u8054\u5408\u6cbb\u7597\u65b9\u6848\u7684I\/II\u671f\u7814\u7a76\u7ed3\u679c\u5df2\u53d1\u8868\u4e8e\u300aThe Lancet Respiratory Medicine\u300b\uff0c\u663e\u793a\u5728\u4e00\u7ebf\u60a3\u8005\u4e2d\u53d6\u5f9771%\u7684\u5ba2\u89c2\u7f13\u89e3\u7387\u548c12.2\u4e2a\u6708\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u3002<\/p>\n\n\n\n

\u8fc7\u53bb\u4e00\u5e74\u4e2d\uff0c\u6208\u6765\u96f7\u585e\u591a\u9879\u4e34\u5e8a\u7814\u7a76\u6210\u679c\u9646\u7eed\u53d1\u8868\u4e8e\u56fd\u9645\u5b66\u672f\u671f\u520a\uff0c\u5305\u62ec\u300aNature Medicine\u300b\u300aThe Lancet Respiratory Medicine\u300b\u548c\u300aThe Lancet Gastroenterology & Hepatology\u300b\u3002<\/p>\n\n\n\n

pan-KRAS<\/strong>\u6291\u5236\u5242<\/strong> JAB-23E73<\/strong><\/p>\n\n\n\n

JAB-23E73\u662f\u4e00\u6b3e\u53e3\u670d\u5c0f\u5206\u5b50pan-KRAS\u6291\u5236\u5242\uff0c\u76ee\u524d\u6b63\u5728\u4e2d\u56fd\u548c\u7f8e\u56fd\u5f00\u5c55\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n\n\n\n

\u622a\u81f32026\u5e741\u670815\u65e5\uff0c\u4e2d\u56fd\u4e00\u671f\u8bd5\u9a8c\u5171\u5165\u7ec442\u4f8b\u60a3\u8005\u300211.9%\u7684\u60a3\u8005\u51fa\u73b0\u4e09\u7ea7\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff0c\u672a\u89c2\u5bdf\u5230\u56db\u7ea7\u6216\u4e94\u7ea7\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u3002\u5728\u9884\u6d4b\u6709\u6548\u5242\u91cf\u8303\u56f4\u5185\u768413\u4f8b\uff08\u5305\u62ec2\u4f8b\u4e8c\u7ebf\u548c11\u4f8b\u4e09\u7ebf\u53ca\u4e09\u7ebf\u4ee5\u4e0a\uff09\u80f0\u817a\u764c\u60a3\u8005\u4e2d\uff0c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a38.5%\uff08\u5176\u4e2d\u5305\u62ec\u5df2\u786e\u8ba4\u548c\u672a\u786e\u8ba4PR\uff09\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u4e3a84.6%\u3002<\/p>\n\n\n\n

\u6b64\u5916\uff0cJAB-23E73\u8054\u5408\u767d\u86cb\u767d\u7ed3\u5408\u578b\u7d2b\u6749\u9187\u548c\u5409\u897f\u4ed6\u6ee8\u7528\u4e8eKRAS\u7a81\u53d8\u80f0\u817a\u764c\u4e00\u7ebf\u6cbb\u7597\u7684Ph Ib\/III \u4e34\u5e8a\u8bd5\u9a8c\u5df2\u4e8e2026\u5e742\u6708\u83b7\u5f97\u56fd\u5bb6\u836f\u76d1\u5c40\u836f\u5ba1\u4e2d\u5fc3\u6279\u51c6\u3002<\/p>\n\n\n\n

ADC<\/strong>\u9879\u76ee<\/strong><\/p>\n\n\n\n

\u52a0\u79d1\u601d\u6301\u7eed\u63a8\u8fdb\u5176\u57fa\u4e8e\u529f\u80fd\u6027\u8f7d\u8377\u7684xADC\u5e73\u53f0\u3002<\/p>\n\n\n\n

JAB-BX600<\/strong>\uff08<\/strong>EGFR-KRAS G12Di tADC<\/strong>\uff09<\/strong>
\u8be5\u9879\u76ee\u4ee5EGFR\u6297\u4f53\u4e3a\u9776\u5411\u3001KRAS G12D\u6291\u5236\u5242\u4e3a\u8f7d\u8377\uff0c\u53ef\u5b9e\u73b0\u7cbe\u51c6\u9012\u9001\u5e76\u5f62\u6210\u53cc\u91cd\u4f5c\u7528\u673a\u5236\uff0c\u4ee5\u514b\u670dKRAS\u6291\u5236\u5242\u5355\u836f\u6cbb\u7597\u4ea7\u751f\u7684\u53cd\u9988\u8010\u836f\u3002\u8be5\u9879\u76ee\u9884\u8ba1\u4e8e2026\u5e74\u4e0b\u534a\u5e74\u63d0\u4ea4IND\u7533\u8bf7\u3002<\/p>\n\n\n\n

JAB-BX467<\/strong>\uff08<\/strong>HER2-STINGa iADC<\/strong>\uff09<\/strong>
\u8be5\u9879\u76ee\u4ee5HER2\u4e3a\u6297\u4f53\u3001STING agonist\u4e3a\u8f7d\u8377\uff0c\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u62db\u52df\u6dcb\u5df4\u7ec6\u80de\uff0c\u5c06”\u51b7\u80bf\u7624”\u8f6c\u5316\u4e3a”\u70ed\u80bf\u7624”\uff0c\u5e76\u6709\u671b\u89e3\u51b3PD-1\u6297\u4f53\u65e0\u54cd\u5e94\u7684”\u51b7\u80bf\u7624”\u6cbb\u7597\u56f0\u5883\u3002\u8be5\u9879\u76ee\u9884\u8ba1\u4e8e2026\u5e74\u4e0b\u534a\u5e74\u63d0\u4ea4IND\u7533\u8bf7\u3002<\/p>\n\n\n\n

\u8d22\u52a1\u60c5\u51b5<\/strong><\/p>\n\n\n\n

\u622a\u81f32025\u5e74\u672b\uff0c\u516c\u53f8\u73b0\u91d1\u53ca\u73b0\u91d1\u7b49\u4ef7\u7269\u53ca\u94f6\u884c\u6388\u4fe1\u5408\u8ba1\u7ea6\u4eba\u6c11\u5e0115.3\u4ebf\u5143\uff0c\u6536\u652f\u7ed3\u4f59\u4e3a\u6b63\u3002\u516c\u53f8\u9884\u8ba12026\u5e74\u7b2c\u4e00\u5b63\u5ea6\u8be5\u4f59\u989d\u5c06\u8d85\u8fc720\u4ebf\u5143\uff0c\u5e76\u9884\u8ba12026\u5e74\u5b9e\u73b0\u626d\u4e8f\u4e3a\u76c8\u3002<\/p>\n\n\n\n

\u5173\u4e8e\u52a0\u79d1\u601d\u836f\u4e1a<\/strong><\/p>\n\n\n\n

\u52a0\u79d1\u601d\u836f\u4e1a\uff081167.HK\uff09\u81f4\u529b\u4e8e\u4e3a\u60a3\u8005\u63d0\u4f9b\u7a81\u7834\u6027\u6cbb\u7597\u65b9\u6848\u3002\u52a0\u79d1\u601d\u62e5\u6709\u8bf1\u5bfc\u53d8\u6784\u836f\u7269\u53d1\u73b0\u5e73\u53f0\uff0c\u6838\u5fc3\u9879\u76ee\u56f4\u7ed5 KRAS\u548cSTING\u4fe1\u53f7\u901a\u8def\u5e03\u5c40\u3002\u516c\u53f8\u613f\u666f\u662f\u4e0e\u5408\u4f5c\u4f19\u4f34\u643a\u624b\u5171\u8fdb\uff0c\u6210\u4e3a\u5168\u7403\u8ba4\u53ef\u7684\u836f\u7269\u7814\u53d1\u9886\u5bfc\u8005\u3002\u5b9e\u9a8c\u5ba4\u4f4d\u4e8e\u4e2d\u56fd\u5317\u4eac\u3001\u4e0a\u6d77\u548c\u7f8e\u56fd\u6ce2\u58eb\u987f\uff0c\u4e34\u5e8a\u8bd5\u9a8c\u8986\u76d6\u4e2d\u56fd180\u4f59\u5bb6\u3001\u7f8e\u56fd30\u4f59\u5bb6\u548c\u6b27\u6d32\u591a\u4e2a\u56fd\u5bb6\u7684\u5341\u4f59\u4e2a\u4e34\u5e8a\u7814\u7a76\u4e2d\u5fc3\u3002<\/p>\n\n\n\n

\u7531CXOUNION-CXO\u8054\u76df\uff08cxounion.cn\uff09<\/a>\u8f6c\u8f7d\u800c\u6210\uff0c\u6765\u6e90\u4e8e\u52a0\u79d1\u601d\u836f\u4e1a\uff1b\u7f16\u8f91\/\u7ffb\u8bd1\uff1aCXOUNIONCXO\u8054\u76df\u5c0fO\u3002<\/p>\n\n\n\n

\u5982\u9700\u52a0\u5165CXO UNION\uff08CXO\u8054\u76df\uff09<\/a>\u9ad8\u7ba1\u793e\u7fa4\uff0c\u8bf7\u8054\u7cfb\u793e\u7fa4\u5c0f\u4f19\u4f34\u54e6~<\/p>\n\n\n\n

\"\"\/<\/figure>\n\n\n\n

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