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\u4e0e\u6b64\u540c\u65f6\uff0c\u4e01\u5217\u660e\u4e3b\u5bfc\u8bbe\u7acb\u7684\u8d1d\u8fbe\u751f\u7269\u533b\u836f\u4ea7\u4e1a\u57fa\u91d1\u4e5f\u5df2\u6295\u8d44\u51e0\u5341\u5bb6\u533b\u836f\u521b\u65b0\u4f01\u4e1a\uff0c\u4e09\u5bb6\u5df2\u6210\u529f\u4e0a\u5e02\u3002\u7279\u522b\u503c\u5f97\u4e00\u63d0\u7684\u662f\u6295\u8d44\u7684\u6b66\u6c49\u79be\u5143\u751f\u7269\u79d1\u6280\u80a1\u4efd\u6709\u9650\u516c\u53f8\uff0c\u5176\u81ea\u4e3b\u7814\u53d1\u7684\u690d\u7269\u6e90\u91cd\u7ec4\u4eba\u8840\u6e05\u767d\u86cb\u767d\u6ce8\u5c04\u6db2\uff0c\u662f\u76ee\u524d\u5168\u7403\u552f\u4e00\u4e00\u4e2a\u5e94\u7528\u690d\u7269\u8868\u8fbe\u4f53\u7cfb\u5c06\u91cd\u7ec4\u4eba\u8840\u6e05\u767d\u86cb\u767d\uff0c\u4e34\u5e8a\u610f\u4e49\u5341\u5206\u5de8\u5927\uff0c\u53ef\u89e3\u9664\u5bf9\u8fdb\u53e3\u4ea7\u54c1\u7684\u4f9d\u8d56\uff0c\u4e5f\u5df2\u83b7\u6279\u8fdb\u5165\u4e34\u5e8a\u7814\u7a76\uff0c\u524d\u666f\u53ef\u671f\u3002CXO UNION-CXO\u8054\u76df\uff08cxounion.cn\uff09<\/mark><\/p>\n\n\n\n

\u8c08\u53ca\u672a\u6765\u53d1\u5c55\uff0c\u4e01\u5217\u660e\u4fe1\u5fc3\u6ee1\u6ee1\u3002\u201c\u5728\u2018\u516b\u516b\u6218\u7565\u2019\u6307\u5f15\u4e0b\uff0c20\u5e74\u521b\u65b0\u521b\u4e1a\u5386\u7a0b\u4e2d\uff0c\u6211\u4eec\u89c1\u8bc1\u4e86\u6d59\u6c5f\u5927\u5730\u7ffb\u5929\u8986\u5730\u7684\u53d8\u5316\uff0c\u5145\u5206\u611f\u53d7\u5230\u4e86\u6d59\u6c5f\u65e0\u6bd4\u4f18\u8d8a\u7684\u521b\u65b0\u521b\u4e1a\u73af\u5883\u548c\u6c11\u8425\u7ecf\u6d4e\u53d1\u5c55\u7684\u72ec\u7279\u4f18\u52bf\u3002\u201d\u4e01\u5217\u660e\u8868\u793a\uff0c\u8fd1\u671f\uff0c\u515a\u4e2d\u592e\u3001\u56fd\u52a1\u9662\u51fa\u53f0\u300a\u5173\u4e8e\u4fc3\u8fdb\u6c11\u8425\u7ecf\u6d4e\u53d1\u5c55\u58ee\u5927\u7684\u610f\u89c1\u300b\uff0c\u7701\u59d4\u3001\u7701\u653f\u5e9c\u53ec\u5f00\u6c11\u8425\u4f01\u4e1a\u5bb6\u5ea7\u8c08\u4f1a\uff0c\u7814\u7a76\u5236\u8ba2\u6d59\u6c5f\u4fc3\u8fdb\u6c11\u8425\u7ecf\u6d4e\u9ad8\u8d28\u91cf\u53d1\u5c55\u7684\u4e3e\u63aa\uff0c\u8ba9\u5927\u5bb6\u5207\u5b9e\u611f\u5230\u65b0\u4e00\u8f6e\u521b\u65b0\u521b\u4e1a\u7684\u597d\u65f6\u4ee3\u5df2\u7ecf\u5230\u6765\uff0c\u624e\u6839\u6d59\u6c5f\u8fd9\u5757\u6c11\u8425\u7ecf\u6d4e\u53d1\u5c55\u6c83\u571f\uff0c\u8d1d\u8fbe\u4e00\u5b9a\u4f1a\u8fce\u6765\u65b0\u7684\u53d1\u5c55\u673a\u9047\u3002<\/p>\n\n\n\n

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\"\"\/<\/figure>\n\n\n\n

\u7ffb\u8bd1\uff1a<\/h2>\n\n\n\n

This heavy report by the People’s Daily and China News Service reporters, which took a year to collect and write, has aroused a wide and warm response in all sectors of the province in recent days.<\/p>\n\n\n\n

“It was the General secretary’s instructions that illuminated our journey to pursue our dreams, allowing us to accomplish what we could not do in the United States. And realize the dream and value of innovation and entrepreneurship.” This time, it has been reported by the provincial authoritative media, which is a great affirmation and incentive for Beida. And further inspires our confidence and determination to climb the world’s scientific and technological peak.”CXO UNION-CXO\u8054\u76df\uff08cxounion.cn\uff09<\/mark><\/p>\n\n\n\n

The new drug Kemena (Ectinib hydrochloride), which was approved by the General Secretary, was listed in 2011 and has benefited more than 500,000 patients with advanced non-small cell lung cancer in the past 12 years. This new drug, independently developed by Dr. Ding Liming led by the overseas high-level talent team. Is China’s first small molecule targeted anti-cancer drug, breaking the monopoly of imported drugs, known as the “two bombs and one star” in the field of people’s livelihood, and won the first and so far the only National science and Technology Progress Prize in China’s chemical pharmaceutical industry and Zhejiang business community.<\/p>\n\n\n\n

Following Kemena, he led the team to successfully develop China’s first innovative drug Bemena (Enshatinib hydrochloride) for lung cancer ALK mutation, the first targeted drug Vomena (Vonib) for the treatment of kidney cancer, the third-generation EGFR-TKI Semena (Befortinib mesylate) and the first Bevacizumab biosimilar in Zhejiang Province, Beantin.CXO UNION-CXO\u8054\u76df\uff08cxounion.cn\uff09<\/mark><\/p>\n\n\n\n

At present, there are more than 40 new drugs in the research and development, of which 18 have entered the clinical stage.<\/h2>\n\n\n\n

Beida, established 20 years ago, has advanced bravely in the surging wave of private economic development and pharmaceutical innovation, as a pioneer, practitioner and beneficiary, has grown from a start-up with only a few people to a listed company with nearly 2,000 employees, becoming the benchmark in the field of Chinese pharmaceutical innovation, and is moving toward “multinational pharmaceutical enterprises headquartered in China”. “Make good medicine, let the people live better, this is the mission of Beida, and we have always adhered to the original heart.” Ding Liming said.<\/p>\n\n\n\n

Ding Lieming was born in a small mountain village in Shihuang Town, Shengzhou City in 1963. In 1979, at the age of 16, he took advantage of the “spring breeze” of the resumption of the National college entrance examination and was admitted to Zhejiang Medical University (now Zhejiang University). In 1984, after graduating from university. Ding Liming was assigned to Shengxian health and epidemic prevention station as an intern researcher. <\/p>\n\n\n\n

He did not stop the pace of further study, two years later admitted to Zhejiang Medical University master’s degree, in 1989 with excellent results graduated to teach in the school, in 1992 as a visiting scholar was sent to the United States to study. During his time in the United States, Ding Leeming studied hard and worked hard, earning a doctorate in pathology from the University of Arkansas and becoming a respected licensed pathologist.<\/p>\n\n\n\n

Having studied and worked in the United States for many years, <\/h2>\n\n\n\n

Ding has witnessed the gap between China and the United States in the fields of economy. Science and technology, especially in the field of pharmaceutical innovation. Growing up in New China, he has always had the idea of serving the motherland in his heart. From the first day he set foot on the United States. The idea of returning home has always haunted his heart, but has been waiting for the opportunity. And the research and development of new drugs is the best opportunity.CXO UNION-CXO\u8054\u76df\uff08cxounion.cn\uff09<\/mark><\/p>\n\n\n\n

In the summer of 2002, the opportunity finally came. <\/h2>\n\n\n\n

The start-up team of several Chinese scientists designed and synthesized a targeted anti-cancer drug and obtained excellent laboratory data. However, in the United States, it takes at least one billion dollars to push forward the implementation of project results, which can not be achieved by a single person or a small team, the team can only develop a period of early development, and finally sell to a large company.<\/p>\n\n\n\n

At that time, the development of new drugs in China was still in a virgin territory. Most of them were generic drugs. There were few new drugs independently developed. And cutting-edge new drugs that could compete with international competition were rare. However, China is becoming a hot land for innovation and entrepreneurship, with rapid economic development and increasingly abundant capital, China has the ability and willingness to invest in high-tech projects, and the market is also large. Standing at the crossroads, where to go? <\/p>\n\n\n\n

The answer is self-evident. Ding Lieming said: “At that time, after discussion, we agreed that if we want to make this project system. We should return to China. Soon, we made a decision: come back to start a business! Dedicate the results to the motherland and the people, and strive to let Chinese patients eat the medicine made by Chinese people!” On August 13, 2002, Ding Liming boarded the Pan American Airlines flight at the airport in Little Rock, Arkansas, saying goodbye to the United States after 10 years of hard work and resolutely returning home to start his new journey of entrepreneurship.<\/p>\n\n\n\n

On January 7, 2003, Beida Pharmaceutical was established in three rented offices on the Stadium Road in Hangzhou. <\/h2>\n\n\n\n

And rented a laboratory in a university in Beijing to establish the Beijing New Drug Research and Development Center. Which began the research and development of new drugs. Innovation is difficult, and making innovative drugs is even more difficult. There is a popular “double Ten” saying in the international medical industry, that is. It takes an average of 10 years to develop a new drug and an investment of 1 billion dollars. <\/p>\n\n\n\n

From technology, capital, to approval, clinical trials, and then to the market, every key node is a big test. Ding Lieming recalled that the domestic new drug research and development environment at that time was not mature, to achieve from “0” to “1”, each step was extremely difficult, to overcome countless technical difficulties, experienced repeated failures, and capital, approval and industrialization. Innovation is difficult, and making innovative drugs is even more difficult. There is a popular “double Ten” saying in the international medical industry, that is. It takes an average of 10 years to develop a new drug and an investment of 1 billion dollars.CXO UNION-CXO\u8054\u76df\uff08cxounion.cn\uff09<\/mark><\/p>\n\n\n\n

From technology, capital, to approval, clinical trials. <\/h2>\n\n\n\n

And then to the market, every key node is a big test. Ding Lieming recalled that the domestic new drug research and development environment at that time was not mature, to achieve from “0” to “1”, each step was extremely difficult, to overcome countless technical difficulties, experienced repeated failures, and capital, approval and industrialization.<\/p>\n\n\n\n

At the critical moment, the district Party committee and the district government offered a helping hand in the middle of the crisis, and provided 15 million yuan of financial support through the subordinate venture capital guidance fund, which suddenly solved the urgent need. The national major new drug creation special fund launched in 2008 also provided strong support. And Zhejiang Province and Hangzhou City also supported in different ways, and Beda made up for the funding gap. Come back from the dead! In February 2009, the Phase III clinical trial of Kemena was initiated.<\/p>\n\n\n\n

The Phase III clinical trial was supervised by Sun Yan, a leading oncologist in China . And Cancer Hospital of the Chinese Academy of Medical Sciences. In order to ensure success, Ding Lieming gave full play to his professional expertise and decided to break the conventional clinical trial design at that time, and for the first time chose international brand patented drugs as positive controls to conduct a head-to-head randomized double-blind trial. It was an extremely risky trial plan that would have been wasted . If the data was worse than the control drug. But the team decided to take the risk because they had enough confidence in their product. CXO UNION-CXO\u8054\u76df\uff08cxounion.cn\uff09<\/mark><\/p>\n\n\n\n

The results of the trial were very encouraging, and Kemena outperformed imported drugs in terms of efficacy and safety. <\/h2>\n\n\n\n

As soon as the data was released, many investment companies and multinational pharmaceutical companies came to the door, including a multinational company that offered a high price of $250 million to buy the project. Although the bank arrears Beida was carrying at that time had reached 150 million yuan, Ding Lieming still refused the other party’s acquisition intention without hesitation, because he always kept in mind the original intention of “doing a good job of medicine, so that the people live better”.<\/p>\n\n\n\n

When Kaimena was listed, although the efficacy and safety were better than imported drugs, Dante listed still insisted on pricing 30% to 40% lower than imported drugs, all in order to make more patients affordable to eat the good drugs independently developed by Chinese people. Let the patient see the hope of life, no longer “talk about cancer change color”. Is to be a good medicine that the people can eat and afford. In 2011, after the official listing of Kaimena . In order to better help patients solve the economic difficulties of long-term drug use. <\/p>\n\n\n\n

Beda on the basis of substantial price reduction.<\/h2>\n\n\n\n

And then carry out follow-up free drug projects, as long as patients take Kaimena for 6 months is really effective. With the relevant certificate issued by the doctor, you can get lifelong follow-up free drug. Drug giveaways are not uncommon, but few are free for life. Nowadays, Kaimena free medicine has reached more than 8.1 million boxes. And the market value has exceeded 13 billion yuan. Which can indeed be said to be a “good medicine that people can afford”.CXO UNION-CXO\u8054\u76df\uff08cxounion.cn\uff09<\/mark><\/p>\n\n\n\n

In addition to the free donation of drugs. Beida also took up the role of national pharmaceutical enterprises in the process of entering the medical insurance of anti-cancer drugs. At the end of 2016, the negotiation of the national medical insurance catalogue was fully opened. And Kemena participated in the negotiation as the first domestic new drug. As we all know, if a drug wants to enter the medical insurance catalogue, it must first reduce its sales price significantly, sometimes even more than half, which is unacceptable for many foreign companies. Therefore, after the start of the national talks. There has been no breakthrough in the anti-cancer drugs that have attracted much attention from patients. <\/p>\n\n\n\n

When the negotiations reached an impasse.<\/h2>\n\n\n\n

Beida took the initiative to stand out and took the lead in promising a price reduction of 54%, which resolutely cut prices, so that foreign companies that previously relied on high prices to occupy the Chinese market were caught off guard, and could only compromise, and also significantly cut prices to enter the medical insurance, so that Chinese patients could benefit. At that time, the leader of the national medical insurance department said with emotion that there was no innovative drug independently developed by Beda, and it was unthinkable to want foreign companies to lower their prices before.<\/p>\n\n\n\n

In 2017, Bayda once again responded to the national call. Pushing Kemena to reduce prices by 3.86% on the basis of a 54% reduction in the national drug price negotiation. In 2021, Kemena postoperative adjuvant therapy indications were approved. And once again significantly reduced prices were included. In the new version of the national medical insurance catalog to better benefit patients. <\/p>\n\n\n\n

Also included in the national medical insurance directory and the implementation of free drug policy, there is Bemena. Nowadays, the applicable advanced lung cancer patients are basically using targeted drugs. And the treatment cost is no longer hundreds of thousands as before. And the significantly reduced drug cost greatly reduces the economic burden of patients. Truly allowing patients in need to use life-saving drugs. Making the tragedy of cancer patients who cannot use life-saving drugs described in the movie “I am Not a Medicine God” become history. Kemena and Bemena were also selected for the national “13th Five-Year” scientific and Technological Innovation Achievement Exhibition.CXO UNION-CXO\u8054\u76df\uff08cxounion.cn\uff09<\/mark><\/p>\n\n\n\n

Innovation is the foundation of life, is Beda’s innate genes.<\/h2>\n\n\n\n

To this end, Beida gathers outstanding talents, builds a leading domestic tumor targeted innovative drug research and development and industrialization system, has two new drug research and development centers in Hangzhou and Beijing, builds a new drug industrialization base in Linping and Shengzhou, and continuously increases the investment in new drug research and development, in recent years, 40% of the operating income is invested in research and development. <\/p>\n\n\n\n

At present, in addition to the 5 products that have been listed, there are more than 40 new drug research projects, covering targeted new drugs and immunotherapies, and a variety of anti-cancer new drug mechanisms of small and large molecules, 18 of which have entered the clinical research stage, and the future development is full of potential.<\/p>\n\n\n\n

At the same time of independent innovation<\/h2>\n\n\n\n

Ding Liming gave full play to Beda’s leading role as a leading enterprise. Led the creation of the biomedical industry incubation platform Beda Dream Workshop. llocated space and funds to help more scientists innovate and start businesses. <\/p>\n\n\n\n

Now, Beda Dream Factory has incubated dozens of pharmaceutical companies, the most prominent representative is Ruepu Technology, founded in cooperation with Professor Deng Hongkui of Peking University, to carry out transformational research on stem cell treatment of diabetes. Now, the project has entered clinical research, the first patient has shown good efficacy and safety, in the international leading level.<\/p>\n\n\n\n

At the same time, the Beida Biomedicine Industry Fund led by Ding Liming has also invested in dozens of pharmaceutical innovation companies. And three have been successfully listed. Especially worth mentioning is the investment of Wuhan Heyuan Biotechnology its independent research and development of plant source recombinant human serum albumin injection. Is currently the world’s only application of plant expression system will recombinant human serum albumin, clinical significance is very great, can remove the dependence on imported products, has also been approved to enter clinical research, the prospect can be expected.CXO UNION-CXO\u8054\u76df\uff08cxounion.cn\uff09<\/mark><\/p>\n\n\n\n

When it comes to future development, Ding Lieming is full of confidence. <\/h2>\n\n\n\n

“Under the guidance of the ’88 Strategy’, in the course of 20 years of innovation and entrepreneurship, we have witnessed earth-shaking changes in Zhejiang, and fully felt the unique advantages of Zhejiang’s unparalleled innovation and entrepreneurship environment and private economic development.” Ding Liming said that recently, the Party Central Committee and The State Council issued the Opinions on Promoting the Development. And Growth of the Private Economy.<\/p>\n\n\n\n

And the provincial Party Committee and the provincial government convened a forum for private entrepreneurs to study and formulate measures to promote the high-quality development of the private economy in Zhejiang, so that everyone can truly feel that a good era of a new round of innovation and entrepreneurship has arrived, and take root in the fertile soil for the development of the private economy in Zhejiang. Beida will surely embrace new development opportunities.CXO UNION-CXO\u8054\u76df\uff08cxounion.cn\uff09<\/mark><\/p>\n\n\n\n

“With the opening of the Asian Games in Hangzhou, people will feel the importance of health more deeply.<\/h2>\n\n\n\n

” Ding Liming said that 20 years in the prime of youth, standing at a new starting point, Beda will bear in mind the spirit of the General Secretary’s instructions, focus on the health needs of the people, give full play to the main role of private enterprises in scientific and technological innovation. <\/p>\n\n\n\n

And strive to develop more good medicines that the people can afford to eat. In order to promote the high-quality development of Zhejiang’s biomedical industry and private economy. Continue to make new contributions to the construction of life and health science and innovation highland . And create an “important window”.<\/p>\n\n\n\n

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\"\"\/<\/figure>\n\n\n\n

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